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Welcome to the Soya Lab!

Exercise Biochemistry and Neuroendocrinology

Brains and Brawn, One and the Same.
Development the best physical exercise program
for "Brain fitness"

News
New Tyrosine as a Mechanistic-Based Biomarker for Brain Glycogen Decrease and Supercompensation With Endurance Exercise in Rats: A Metabolomics Study of Plasma （Matsui et al.） was accepted Front. Neurosci. !
Rapid stimulation of human dentate gyrus function with acute mild exercise (Suwabe, Byun et al.) was accepted Proc. Natl. Acad. Sci. USA !
Riluzole reduces amyloid beta pathology, improves memory, and restores gene expression changes in a transgenic mouse model of early-onset Alzheimer's disease (Okamoto et al.) was accepted Transl Psychiatry !
Thiamine tetrahydrofurfuryl disulfide promotes voluntary activity through dopaminergic activation in the medial prefrontal cortex（Saiki et al.) was accepted Scientific Reports !
Hypoxia-induced lowered executive function depends on arterial oxygen desaturation (Ochi et al.) was accepted The Journal of Physiological Sciences. !
Hyper-hippocampal glycogen induced by glycogen loading with exhaustive exercise （Soya et al.) was accepted Scientific Reports !
A transferable high-intensity intermittent exercise improves executive performance in association with dorsolateral prefrontal activation in young adults (Kujach, Byun et al.) was accepted NeuroImage !
Role of the astroglial glutamate exchanger xCT in ventral hippocampus in resilience to stress was accepted Neuron !
Aerobic fitness associates with mnemonic discrimination as a mediator of physical activity effects: evidence for memory flexibility in young adults (Suwabe et al.) was accepted by Scientific Reports！
Astrocytic glycogen-derived lactate fuels the brain during exhaustive exercise to maintain endurance capacity (Matsui et al.) was accepted by Proc. Natl. Acad. Sci. USA！
Current Topics
Thiamine tetrahydrofurfuryl disulfide promotes voluntary activity through dopaminergic activation in the medial prefrontal cortex
Saiki M, Matsui T, Soya M, Kashibe T, Shima T, Shimizu T, Naruto T, Kitayoshi T, Akimoto K, Ninomiya S, Soya H. Sci Rep, 2018 Jul 11.
Hyper-hippocampal glycogen induced by glycogen loading with exhaustive exercise
Soya M, Matsui T, Shima T, Jesmin S, Omi N, Soya H. Sci Rep, 2018 Jan 19.
Neural basis for reduced executive performance with hypoxic exercise
Ochi G, Yamada Y, Hyodo K, Suwabe K, Fukuie T, Byun K, Dan I, Soya H. Neuroimage, 2018 May 1.
A transferable high-intensity intermittent exercise improves executive performance in association with dorsolateral prefrontal activation in young adults
Kujach S, Byun K, Hyodo K, Suwabe K, Fukuie T, Laskowski R, Dan I, Soya H. Neuroimage, 2017 Dec 5.
Aerobic fitness associates with mnemonic discrimination as a mediator of physical activity effects: evidence for memory flexibility in young adults
Suwabe K, Hyodo K, Byun K, Ochi G, Fukuie T, Shimizu T, Kato M, Yassa MA, Soya H. Sci Rep, 2017
Astrocytic glycogen-derived lactate fuels the brain during exhaustive exercise to maintain endurance capacity.
Matsui T, Omuro H, Liu YF, Soya M, Shima T, McEwen BS and Soya H. Proc Natl Acad Sci USA. 2017 May.
Acute moderate exercise improves mnemonic discrimination in young adults.
Suwabe K, Hyodo K, Byun K, Ochi G, Yassa MA, Soya H.Hippocampus. 2017 Mar.
Moderate exercise ameliorates dysregulated hippocampal glycometabolism and memory function in a rat model of type 2 diabetes.
Shima T, Matsui T, Jesmin S, Okamoto M, Soya M, Inoue K, Liu YF, Torres-Aleman I, McEwen BS and Soya H. Diabetologia, 2016 Dec 8.
The association between aerobic fitness and cognitive function in older men mediated by frontal lateralization.
Hyodo K, Dan I, Kyutoku Y, Suwabe K, Byun K, Ochi G, Kato M, Soya H. Neuroimage. 2016 Jan 15
Positive effect of acute mild exercise on executive function via arousal-related prefrontal activations: An fNIRS study.
Byun K, Hyodo K, Suwabe K, Ochi G, Sakairi Y, Kato M, Dan I, Soya H. NeuroImage 98: pp336-345, 2014.

Acute moderate exercise enhances compensatory brain activation in older adults.
Hyodo K, Dan I, Suwabe K, Kyutoku Y, YamadaY, Akahori M, Byun K, Kato M, Soya H. Neurobiol Aging, 33: pp2621-2632,2012.
Voluntary resistance running with short distance enhances spatial memory related to hippocampal BDNF signaling.
Lee MC, Okamoto M, Liu YF, Inoue K, Matsui T, Nogami H, Soya H. J Appl Physiol. 113: pp1260-1206, 2012.

Mild exercise increases dihydrotestosterone in hippocampus providing evidence for androgenic mediation of neurogenesis.
Okamoto M, Hojo Y, Inoue K, Matsui T, Kawato S, McEwen BS, Soya H. Proc Natl Acad Sci USA, 109: pp13100-13105, 2012.

Brain glycogen supercompensation following exhaustive exercise.
Matsui T, Ishikawa T,Okamoto M, Inoue K, Lee MC, Fujikawa T, Ichitani Y, Kawamata K,Soya H. J Physiol. 590: pp607-616, 2012.
Thiamine tetrahydrofurfuryl disulfide promotes voluntary activity through dopaminergic activation in the medial prefrontal cortex
Saiki M, Matsui T, Soya M, Kashibe T, Shima T, Shimizu T, Naruto T, Kitayoshi T, Akimoto K, Ninomiya S, Soya H. Sci Rep, 2018 Jul 11.
Hyper-hippocampal glycogen induced by glycogen loading with exhaustive exercise
Soya M, Matsui T, Shima T, Jesmin S, Omi N, Soya H. Sci Rep, 2018 Jan 19.
Astrocytic glycogen-derived lactate fuels the brain during exhaustive exercise to maintain endurance capacity.
Matsui T, Omuro H, Liu YF, Soya M, Shima T, McEwen BS and Soya H. Proc Natl Acad Sci USA. 2017 May.
Moderate exercise ameliorates dysregulated hippocampal glycometabolism and memory function in a rat model of type 2 diabetes.
Shima T, Matsui T, Jesmin S, Okamoto M, Soya M, Inoue K, Liu YF, Torres-Aleman I, McEwen BS and Soya H. Diabetologia, 2016 Dec 8.
Voluntary resistance running with short distance enhances spatial memory related to hippocampal BDNF signaling.
Lee MC, Okamoto M, Liu YF, Inoue K, Matsui T, Nogami H, Soya H. J Appl Physiol. 113: pp1260-1206, 2012.

Mild exercise increases dihydrotestosterone in hippocampus providing evidence for androgenic mediation of neurogenesis.
Okamoto M, Hojo Y, Inoue K, Matsui T, Kawato S, McEwen BS, Soya H. Proc Natl Acad Sci USA, 109: pp13100-13105, 2012.

Brain glycogen supercompensation following exhaustive exercise.
Matsui T, Ishikawa T,Okamoto M, Inoue K, Lee MC, Fujikawa T, Ichitani Y, Kawamata K,Soya H. J Physiol. 590: pp607-616, 2012.
Neural basis for reduced executive performance with hypoxic exercise
Ochi G, Yamada Y, Hyodo K, Suwabe K, Fukuie T, Byun K, Dan I, Soya H. Neuroimage, 2018 May 1.
A transferable high-intensity intermittent exercise improves executive performance in association with dorsolateral prefrontal activation in young adults
Kujach S, Byun K, Hyodo K, Suwabe K, Fukuie T, Laskowski R, Dan I, Soya H. Neuroimage, 2017 Dec 5.
Aerobic fitness associates with mnemonic discrimination as a mediator of physical activity effects: evidence for memory flexibility in young adults
Suwabe K, Hyodo K, Byun K, Ochi G, Fukuie T, Shimizu T, Kato M, Yassa MA, Soya H. Sci Rep, 2017
Acute moderate exercise improves mnemonic discrimination in young adults.
Suwabe K, Hyodo K, Byun K, Ochi G, Yassa MA, Soya H.Hippocampus. 2017 Mar.
The association between aerobic fitness and cognitive function in older men mediated by frontal lateralization.
Hyodo K, Dan I, Kyutoku Y, Suwabe K, Byun K, Ochi G, Kato M, Soya H. Neuroimage. 2016 Jan 15
Positive effect of acute mild exercise on executive function via arousal-related prefrontal activations: An fNIRS study.
Byun K, Hyodo K, Suwabe K, Ochi G, Sakairi Y, Kato M, Dan I, Soya H. NeuroImage 98: pp336-345, 2014.

Acute moderate exercise enhances compensatory brain activation in older adults.
Hyodo K, Dan I, Suwabe K, Kyutoku Y, YamadaY, Akahori M, Byun K, Kato M, Soya H. Neurobiol Aging, 33: pp2621-2632,2012.
New York Times / national getgraphic published some articles about our researches.

2018/10/24
Even a 10-Minute Walk May Be Good for the Brain

2018/10/02
Study Suggests Light Exercise Helps Memory

2015/12/09
Does Exercise Help Keep Our Brains Young?

2014/05/07
How 10 minutes of miid exercise gives your brain a boost?

2012/9/12
How Testosterone May Alter The Brain After Exercise

2012/2/22
How Exercise Fuels the Brain

2011/1/19
Brains and Brawn

2009/9/16
What Sort of Exercise Can Make You Smater?